This BioInteractive newsletter features a new CRISPR animation, a Central Dogma card activity, and a fantastic educator tip!Email not displaying correctly?
View it in your browser. APRIL 25, 2018 Find and Replace First described in 2012, CRISPR-Cas9 generated interest both for its exciting potential for treating genetic disease as well as for potential ethical and safety concerns. In this new interactive, explore how CRISPR-Cas9 works and hear from leading scientists like Jennifer Doudna and David Liu about its discovery and applications. Spotlight on: The Central Dogma Express Yourself Understanding how the information in DNA becomes flesh and blood allows researchers to intervene in this process to treat monogenic diseases. With these new activity cards, students order the steps of the central dogma and then apply what they’ve learned to different disease scenarios presented in an accompanying handout. Image of the Week Friend and Foe We normally think of bacteria as harmful. But researchers are using Wolbachia, bacteria that grow in arthropod and nematode hosts, to fight diseases like elephantitis and Dengue fever. Featured Collection A Multitude of Videos Our bodies are hosts to complex microbial ecosystems. Explore more about the microbes on and in us with our ‘I Contain Multitudes’ Collection, produced by HHMI Tangled Bank Studios in partnership with PBS Learning Media. It features short, classroom-friendly videos and supplemental resources. Events and Announcements 15 for 15 National DNA Day commemorates the 15th anniversary of the Human Genome Project. HHMI BioInteractive is partnering with the National Human Genome Research Institute at NIH on the ’15 for 15’ celebration. Check out 15 days of exciting genomics resources arranged by topics from human origins to agriculture. Educator Tip A Doggone Good Resource I’ve used the BioInteractive Resource: “Mapping Genes to Traits in Dogs Using SNPs” with my students for the past few years. It’s a powerful way to have my students practice recognizing patterns, and getting them to understand that the presence or absence of patterns is an important indicator that something is a phenomenon! Students discuss differences between correlation and causation, allowing them see that identifying correlation is just the beginning of the search for causation. I pair this activity with the National Center for Case Study Teaching in Science case study, “What Happened To Beau? How Amino Acids in Keratin Organization in Hair”, which engages students in an investigation of changes that occur in a dog’s hair type as it ages from puppy to adolescent. As part of the case study, students learn about how protein structure determines function and how DNA dictates protein structure – helping them understand causation! By examining heredity, my students cement their understanding of the connection between genotype and phenotype and that inheritance patterns hint at the molecular mechanisms involved in expressed traits. This case study complements the HHMI activity wonderfully; the two resources increase my students’ capacity and facility with the processes of science. - Katie Ward (Aragon High School, CA) Do you have a favorite BioInteractive resource and want to tell us how you use it in your class? Email us the tip at[email protected]. If we feature yours, we'll send you a T-shirt!
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